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Zollinger-Ellison syndrome

1 associated gene
No signs/symptoms info

PROTEIN INTERACTIONS: 1

Primary pigmented nodular adrenocortical disease

3 OMIM references -
3 associated genes
15 signs/symptoms

Zollinger-Ellison syndrome

Primary pigmented nodular adrenocortical disease

MEN1	(UniProt - OMIM)		PDE11A	(UniProt - OMIM)
			PDE8B	(UniProt - OMIM)
			PRKAR1A	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MEN1	(0.49)	PRKAR1A

Citations in the biomedical literature:

Zollinger-Ellison syndrome		Primary pigmented nodular adrenocortical disease
	Synonym(s): - Gastrinoma		Synonym(s): - PPNAD

	Classification (Orphanet): - Rare endocrine disease - Rare gastroenterologic disease - Rare oncologic disease		Classification (Orphanet): - Rare endocrine disease - Rare genetic disease - Rare infertility

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: normal Type of inheritance: sporadic		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: any age Type of inheritance: autosomal dominant

	External references: No OMIM references 2 MeSH references: D015043 / D015408		External references: 3 OMIM references - No MeSH references

Primary pigmented nodular adrenocortical disease
	Very frequent - Adrenal glands anomalies - Cortico-adrenal hyperplasia / hypersecretion Frequent - Asthenia / fatigue / weakness - Chronic arterial hypertension - Diabetes mellitus - Late puberty / hypogonadism / hypogenitalism - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy - Muscle weakness / flaccidity - Mutiple fractures / bone fragility - Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets - Short stature / dwarfism / nanism - Striae - Thin skin - Truncal obesity Occasional - Myopathy
Zollinger-Ellison syndrome
(no data available)